Chasing the BSE agent
نویسندگان
چکیده
منابع مشابه
Chasing the BSE agent
The UK and its anxious neighbours are currently focusing on foot and mouth disease but agricultural researchers are still working on a much deeper and worrying problem: BSE and its human form, new variant CJD. Unlike foot and mouth disease, much remains unknown about the aberrant prion protein agent of BSE and how it causes disease. One of the biggest stumbling blocks to research is the lack of...
متن کاملCharacterization of the murine BSE infectious agent.
Bovine spongiform encephalopathy (BSE) is a prion-associated disease where the infectious agent is thought to be a host-encoded protein with a protease-resistant conformation (PrP(Sc)). Here, data are presented on the solubilization of purified murine BSE material, using guanidine-HCl as a denaturing agent. This treatment led to loss of infectivity, which was partially recovered on renaturation...
متن کاملInactivation of the BSE agent by the heat and pressure process for manufacturing gelatine.
Dietary exposure to the bovine spongiform encephalopathy (BSE) agent is the probable cause of variant Creutzfeldt-Jakob disease in people. The industrial manufacturing process for the production of gelatine and colloidal protein by the heat and pressure process was downscaled accurately and its capacity to remove or inactivate bse infectivity was investigated. Gelatine was made from bones exper...
متن کاملChasing the cell assembly.
Although we know enormous amounts of detailed information about the neurons that make up the cortex, placing this information back into the context of the behaving animal is a serious challenge. The functional cell assembly hypothesis first described by Hebb (The Organization of Behavior; a Neuropsychological Theory. New York: Wiley; 1949) aimed to provide a mechanistic explanation of how group...
متن کاملPruritus is a common feature in sheep infected with the BSE agent
BACKGROUND The variability in the clinical or pathological presentation of transmissible spongiform encephalopathies (TSEs) in sheep, such as scrapie and bovine spongiform encephalopathy (BSE), has been attributed to prion protein genotype, strain, breed, clinical duration, dose, route and type of inoculum and the age at infection. The study aimed to describe the clinical signs in sheep infecte...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2001
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(01)00210-x